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乳头甲状腺癌中的BRAF,TERT和HLA-G状态:临床病理学协会研究

Bruna C Bertol^1,2, Juliana D Massaro³, Guilherme Debortoli⁴

¹Postgraduate Program of Basic and Applied Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil.

International journal of molecular sciences

|August 12, 2023

概括

这项研究研究了皮肤状甲状腺癌 (PTC) 中的BRAF,TERT,HLA-G和microRNA. 虽然单独与PTC相关,但它们对患者结果的综合影响需要进一步研究.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳头甲状腺癌 (PTC) 受BRAF,TERT,HLA-G和microRNAs的影响.
了解这些标记物的相互作用对于PTC预后至关重要.

研究的目的:

评估BRAF,TERT,HLA-G和微RNA在PTC中的单个和联合作用.
为了将这些标记与临床病理特征和患者结果相关联.

主要方法:

对HLA-G和BRAF表达的免疫组织化学.
在精细针吸入物中对BRAF^V600E和TERT促进子突变进行分子分析.
针对微RNA分析进行大规模并行测序.

主要成果:

在PTC标本中观察到HLA-G和BRAF的高表达.
BRAF过度表达与治疗反应不佳相关.
与晚期疾病特征相关的BRAF^V600E和TERT^C228T突变.
与转移性瘤相关的TERT基因型.
确定了9种针对BRAF,TERT和/或HLA-G的微RNA,这些微RNA涉及癌症途径.

结论:

BRAF,TERT,HLA-G和微RNA都与PTC特征单独相关.
建议BRAF^V600E和TERT^C228T之间有一个协同效应.
这些标记物对PTC结果的协作作用需要进一步研究.
针对BRAF和HLA-G的微RNA可能有助于它们的瘤表达.

关键词:

生物标志物生物标志物微RNAs 是一个微型RNA.多态的多态化.甲状腺癌是一种癌症.

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