从自然产品中开发药物,基于喘病原性机制
Min-Hee Kim1, Chun-Sik Bae2, So-Hyeon Bok3
1Department of Forestry and Landscape Architecture, Dongshin University, Naju 58245, Republic of Korea.
International journal of molecular sciences
|August 12, 2023
概括
喘影响全球数以百万计的人,导致大量的死亡率. 从天然产品开发新的喘治疗方法是有希望的,因为它们的潜在抗炎和免疫调节作用.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘是一种慢性,全球性肺炎性疾病,影响超过2.62亿人,死亡率很高.
- 患病率正在增加,特别是在儿童和老年人中,这构成了越来越大的公共卫生挑战.
- 目前的喘治疗主要是治疗症状,并产生不良影响,需要新的治疗策略.
研究的目的:
- 审查当前对喘病理生理学的理解.
- 突出现有的喘药物的局限性和不良影响.
- 探索天然产品作为新喘药物开发来源的潜力.
主要方法:
- 关于喘流行病学,病理生理学和治疗选择的文献综述.
- 分析当前的喘药物类别,它们的机制和副作用.
- 探索对具有潜在抗喘功能的天然产品的研究.
主要成果:
- 喘涉及复杂的机制,包括Th1/Th2不平衡,肺炎和异常细胞亡/增殖.
- 现有的喘药物 (缓解剂和控制剂) 有显著的不良影响,如免疫抑制和生长迟缓.
- 天然产品显示出潜在的抗喘活性,包括免疫调节,抗炎症和亡调节.
结论:
- 迫切需要更安全,更有效的喘疗法.
- 自然产品为开发具有多样性治疗作用的新喘药物提供了有希望的途径.
- 对天然产品衍生化合物的进一步研究可能会在喘管理方面取得重大进展.
相关概念视频
Asthma: Pathogenesis and Management
446
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
446
Antiasthma Drugs: Leukotriene Modifiers
357
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
357
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Drugs Used in Lower Respiratory Disorders: Overview
489
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
489
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
346
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
346
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K


