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膀经检测测试:一种新的工具,用于支持尿液样本中的尿癌诊断
Vincenzo Fiorentino1, Cristina Pizzimenti2, Mariausilia Franchina1
1Department of Human Pathology of the Adult and Developmental Age "G. Barresi", University of Messina, 98125 Messina, Italy.
International journal of molecular sciences
|August 12, 2023
概括
膀癌监测从新的尿路生物标志物测试中受益. 甲基化分析,就像膀EpiCheck测试一样,有助于诊断高度泌尿腺癌并预测复发.
科学领域:
- 尿瘤学 尿瘤学
- 分子诊断学 分子诊断学
- 癌症生物标志物 癌症生物标志物
背景情况:
- 膀癌和上泌尿道癌经常复发,需要在治疗后进行勤奋的随访.
- 目前的非肌肉侵入性膀癌 (NMIBC) 管理依赖于监测,静脉内疗法和细胞学和囊镜等诊断程序.
- 国际指导方针建议在NMIBC随访期间进行囊囊镜检查,尿细胞学和放射性评估,以评估上道.
研究的目的:
- 审查甲基化分析和膀EpiCheck测试作为尿路癌细胞瘤尿路生物标志物的重要性.
- 评估这些生物标志物在为NMIBC进行随访的患者诊断尿癌时的有用性.
- 探索它们在支持细胞学和囊镜中的作用,特别是在模两可的情况下,并预测复发.
主要方法:
- 对尿路检测现有文献的审查,重点关注用于膀瘤检测的DNA甲基化标记物.
- 对膀EpiCheck测试的评估,该测试分析尿细胞的甲基化概况.
- 评估细胞学和甲基化分析的综合方法,用于诊断高度泌尿腺癌 (HGUC) 和预测复发.
主要成果:
- 尿细胞学表明,对于检测高度泌尿腺癌 (HGUC) 和 in situ 癌症 (CIS) 的高灵敏度.
- 以膀EpiCheck测试为例的DNA甲基化分析,为检测膀瘤提供了一种新的方法.
- 细胞学和甲基化分析的结合策略显示出对诊断HGUC和预测临床和组织学复发的前景.
结论:
- 甲基化分析,特别是膀EpiCheck测试,是诊断尿路癌在NMIBC随访中的有价值的尿路生物标志物.
- 这种方法可以增强传统的方法,如细胞学和囊镜检查,特别是在不确定的发现的情况下.
- 细胞学和甲基化分析的整合可以改善HGUC的诊断,并提高复发的预测.
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