选择性内部辐射疗法改变了肝细胞癌中全身细胞外囊泡的形状
Severin Gylstorff1,2,3, Vanessa Wilke1,2, Daniel Kraft1,2
1Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto-von-Guericke-University, 39120 Magdeburg, Germany.
International journal of molecular sciences
|August 12, 2023
概括
在接受放射栓塞 (RE) /选择性内部放射治疗 (SIRT) 的肝细胞癌 (HCC) 患者的细胞外囊 (EV) 显示出与治疗成功和生存相关的免疫标记物. 这些EV为监测HCC治疗提供了潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 全球肝细胞癌 (HCC) 发病率正在上升.
- 放射栓塞 (RE) /选择性内部放射治疗 (SIRT) 是不可操作的HCC的关键治疗方法.
- 细胞外囊泡 (EVs) 在细胞通信和瘤进展中发挥作用,影响免疫反应.
研究的目的:
- 调查SIRT/RE前后不可手术的HCC患者中EVs的免疫特征和起源.
- 识别潜在的基于EV的生物标志物,用于预测治疗反应和患者存活率.
主要方法:
- 在SIRT/RE之前和之后收集了50名HCC患者的血液样本.
- 测量了细胞因子,并使用尺寸排除色谱分离了EV.
- 通过流细胞计分析了37个EV表面标记物,并与临床结果相关联.
主要成果:
- 在HCC患者的EV中检测到几种免疫标记物 (例如CD4,CD2,CD40,CD45,CD49e,CD69,CD209).
- 在某些EV标志物 (CD4,CD2,CD40,CD45,CD49e,CD69,CD209) 和治疗反应/生存之间观察到正相关性.
- 相反,EV上的CD20 (B细胞),CD146 (内皮细胞),CD49e和CD41b (血小板) 等标记物与60天生存时间有负相关性.
结论:
- HCC患者的血EV含有免疫学,癌症和凝血标记物.
- 特定的EV表面标记物 (CD4,CD20,CD49e,CD146) 显示出作为HCC生物标记物的潜力.
- EV分析可以提高对HCC生物学的理解,并有助于监测SIRT/RE治疗的有效性.
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