致病性Leptospira种的分子流行病学 在拉丁美洲感染狗
Maria Isabel Nogueira Di Azevedo1, Luiza Aymée1, Ana Luiza Dos Santos Baptista Borges1
1Laboratory of Veterinary Bacteriology, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro 24020-150, Brazil.
Animals : an open access journal from MDPI
|August 12, 2023
概括
拉丁美洲的犬类白病菌株表现出了显著的遗传同质性. 这项研究强调了狗.
科学领域:
- 兽医微生物学 兽医微生物学
- 分子流行病学分子流行病学
- 传染性疾病 传染性疾病
背景情况:
- 狗螺杆菌病是一种严重的细菌性疾病,由 * Leptospira * 螺杆菌引起.
- 虽然在拉丁美洲等热带地区流行,但在狗中循环菌株的分子流行病学仍未得到充分探索.
- 了解菌株动态对于疾病控制和One Health倡议至关重要.
研究的目的:
- 分析拉丁美洲狗中致病性 * Leptospira * 类型的遗传多样性和循环模式.
- 在该地区使用in silico方法阐明犬类白病的分子流行病学.
主要方法:
- 从GenBank.Bank获得的148个DNA序列的化分析.
- 序列修复,对齐和遗传距离的计算.
- 构建最有可能的家族遗传树和哈普洛型网络.
主要成果:
- 在拉丁美洲的狗中发现了一组高度基因同质的 * Leptospira * 菌株.
- 一个主要的单基,与人类循环的菌株Fiocruz L1-130密切相关,是突出的.
- 根据临床病史或地理位置,没有观察到任何显著的遗传变异.
结论:
- 狗具有基因统一的 * Leptospira * 种群,表明其无处不在的循环.
- 这种遗传同质性强调了狗在白病的一种健康传播动态中的关键作用.
- 需要进一步的研究,以了解疾病预防和控制的影响.
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