基因组预测和全基因组关联研究用于野猪污染化合物
Sara Faggion1, Elena Boschi1, Renata Veroneze2
1Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Padova, Italy.
Animals : an open access journal from MDPI
|August 12, 2023
概括
选择对猪污染 (BT) 化合物 (如安德罗) 具有遗传耐药性的猪对于未来禁止手术割至关重要. 基因组选择为androstenone提供了更高的准确性,有助于繁殖策略.
科学领域:
- 动物遗传学动物遗传学
- 畜牧养殖 畜牧养殖 畜牧养殖
- 食品科学 食品科学 食品科学
背景情况:
- 野猪的手术割在欧洲面临潜在的禁令.
- 野猪污染 (BT) 化合物 (androstenone,indole,skatole) 影响猪肉的质量.
- 遗传选择为管理BT提供了割的可持续替代方案.
研究的目的:
- 通过基因组和血统数据估计BT化合物的育种值.
- 识别与BT化合物积累相关的遗传标记.
- 探索候选基因,影响猪的BT和脂肪代谢.
主要方法:
- 在1075只野猪的脂肪组织中量化BT化合物.
- 猪的基因定型在29844个单核酸多态 (SNP).
- 使用基于血统的BLUP (PBLUP) 和基因组BLUP (GBLUP) 估计育种价值.
- 全基因组关联研究 (GWAS) 以确定显著的SNP窗口.
- 在GWAS后进行分析,以确定候选基因.
主要成果:
- 在BT化合物中观察到适度的遗传性 (0.30-0.52).
- 基因组BLUP (GBLUP) 与PBLUP (0.58对0.36) 相比,安德罗斯的准确性显著更高.
- 在GBLUP和PBLUP之间,indole和skatole的准确性是可以比较的 (~0.43对~0.47).
- 确定了几个SNP窗口和18个与BT,繁殖和脂肪代谢相关的候选基因.
结论:
- 基因组选择是改善对野猪污染物,特别是androstenone的抗性的一种有价值的工具.
- 识别的遗传标记可以帮助培育计划减少BT化合物.
- 了解BT的遗传基础,包括它与脂肪代谢的联系,对于可持续的猪生产至关重要.
关键词:
GBLUPUP GBLUP 的意思是什么意思在GWAS中,GWAS就是GWAS.安德罗斯一是一种候选基因是指候选基因的基因.基因组预测 基因组预测印度尔 (Indole) 是一种制剂.斯卡托尔斯卡托尔斯 斯卡托尔斯更多相关视频
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