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纳米颗粒的外细胞分解:综合性审查
Jie Liu1, Yuan-Yuan Liu1, Chen-Si Li1
1Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China.
Nanomaterials (Basel, Switzerland)
|August 12, 2023
概括
了解纳米粒子 (NP) 异位细胞分解对于纳米材料的安全性和设计至关重要. 本综述详细介绍了NP细胞外的机制,影响因素以及生物医学应用的未来研究方向.
科学领域:
- 纳米技术纳米技术
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
背景情况:
- 纳米材料的安全性和应用依赖于了解细胞相互作用.
- 纳米颗粒 (NP) 异位细胞分解比吸收研究较少,但对于细胞NP含量调节和毒性至关重要.
- 调查NP外细胞分裂对于评估NP安全性和设计有效的基于NP的材料至关重要.
研究的目的:
- 综合审查目前对纳米颗粒外细胞形成的理解.
- 总结NP细胞外生成机制,动力学和影响因素.
- 确定在NP外细胞瘤领域的挑战和未来研究方向.
主要方法:
- 对实验程序的审查和对研究NP细胞外的考虑.
- 简要介绍了NP外细胞形成途径,包括 lysosomal 和 ER/Golgi 途径,以及微管的作用.
- 讨论影响NP外细胞形成的因素,如NP特性,细胞类型和细胞外条件.
主要成果:
- 外细胞分裂调节细胞内纳米粒子含量,影响NP毒性.
- 关键的外细胞突变途径涉及溶解体和内质网膜/戈尔吉器官,其中微管体发挥着作用.
- 诸如NP大小,电荷,细胞内含量/位置,细胞类型和环境等因素会影响细胞外的发生率.
结论:
- 较小和充电的纳米粒子通常更容易分泌.
- 对NP细胞外的彻底理解对于安全性评估和纳米材料的合理设计至关重要.
- 需要进一步的研究来解决不一致性,并推进纳米颗粒外细胞形成的领域.
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