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用L-氨酸修饰的转基因因组用于增强皮肤上传送 podophyllotoxin 的作用

Jiangxiu Niu¹, Ming Yuan¹, Jingjing Chen¹

¹College of Food and Drug, Luoyang Normal University, Luoyang 471934, China.

Molecules (Basel, Switzerland)

|August 12, 2023

概括

经L-氨酸修饰的转移体 (LCTs) 增强了皮肤表皮传递的 podophyllotoxin (POD). 这些新型载体改善了皮肤的保留性,并将POD局部化到表皮,而不会引起刺激,这表明它们有可能用于局部药物输送.

科学领域:

制药科学制药科学
皮肤病学皮肤病学
纳米技术纳米技术

背景情况:

局部药物输送在实现有效的表皮透方面面临挑战.
波多菲洛毒素 (POD) 是一种强效的化合物,由于皮肤传递不佳,局部疗效有限.
转移体是有希望的基于脂质的纳米载体,用于通过皮肤递送药物.

研究的目的:

开发和评估L-氨酸修饰转移体 (LCTs) 作为局部载体,用于增强皮肤上传送 podophyllotoxin (POD).
为了研究POD-LCTs的物理化学特性,体外释放,皮肤透,保留和刺激潜力.

主要方法:

合成L-氨酸-脱氧醇酸 (LC-DCA) 结合物.
使用薄膜分散制备POD载荷的L-氨酸修饰转移体 (POD-LCTs).
特性包括粒子大小,泽塔潜力,形态,XRD,FTIR和体外释放研究.
在体外皮肤透,保留,光分布,H&E染色和体内皮肤刺激测试.

主要成果:

POD-LCTs表现出球形形态,粒子大小为172.5 ± 67.2 nm,泽塔电位为-31.3 ± 6.7 mV.
与未经修改的转移体 (POD-Ts) 相比,POD-LCT显示皮肤透率显著降低,皮肤保留率显著增加.
光成像揭示了POD-LCTs在表皮中的偏好定位,与分布更广泛的POD-Ts不同.
在体内没有观察到POD-LCTs的皮肤刺激.

结论:

修改L-氨酸增强了通过转移体通过表皮传递 podophyllotoxin.
POD-LCT显示出作为一种安全有效的局部载体系统的潜力,用于向表皮.
这种方法可能会改善皮肤疾病中 podophyllotoxin 的治疗疗效.

关键词:

在L-氨酸中,L-氨酸含有氨酸.药物输送是药物输送的过程.通过表皮传递.这是一种 podophyllotoxin 毒素.转账额度是指转账额度的转移额度.

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