识别与初级Sjögren病相关的唾液代谢特征
Addy Alt-Holland1,2, Xuejian Huang3, Tatiana Mendez2
1Department of Endodontics, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA.
Molecules (Basel, Switzerland)
|August 12, 2023
概括
核磁共振 (NMR) 光谱学在初级Sjögren患者中确定了不同的唾液代谢特征.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 诊断医学 诊断医学
背景情况:
- 斯约格伦病 (SjD) 是一种普遍存在的自身免疫性疾病,导致慢性外分泌腺炎症.
- 由于症状表现的延迟和诊断方法的局限性,诊断原发性Sjögren病 (pSjD) 是具有挑战性的.
- 目前对pSjD的诊断方法缺乏最佳的灵敏度和选择性,导致诊断延迟.
研究的目的:
- 用核磁共振 (NMR) 光谱来研究psjD患者的唾液代谢概况.
- 为了确定潜在的唾液生物标志物用于对psjD的差异诊断.
- 探索基于NMR的代谢学在临床环境中用于Sjögren病检测的实用性.
主要方法:
- 从30名pSjD受试者和30名非Sjögren对照者 (NS-C) 收集了非刺激的唾液样本.
- 使用NMR光谱学量化34种代谢物,分析了正常化和非正常化数据.
- 应用统计分析,对所有参与者和年龄受限子集的数据进行错误发现率校正.
主要成果:
- 正常化的唾液代谢显示了psjD患者的显著变化,包括葡萄糖,甘,牛,乳酸的增加,以及5-aminopentanoate,乙酸,丁酸,酸的减少.
- 胆和糖等特定代谢物在pSjD亚组中显示出改变的水平.
- 代谢物度数据证实了一些发现,突出显示pSjD患者的葡萄糖,甘油,氨酸和乳酸的增加.
结论:
- NMR代谢学有效地定义了与psjD相关的唾液代谢特征.
- 唾液代谢分析可以帮助区分pSjD患者与健康对照.
- 这种方法有望改善Sjögren病的临床诊断.
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