探索传统发酵过程后来自替代来源的葡萄油的植物化学成分和活体抗炎潜力:对植物疗法的影响
Yancho Zarev1, Lyubomir Marinov2, Denitsa Momekova3
1Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Plants (Basel, Switzerland)
|August 12, 2023
概括
来自发酵种子的葡萄油 (GSO) 在小鼠中显示出抗炎和抗氧化作用,减少了脚的胀. 这种替代GSO提供了潜在的治疗益处,尽管长期使用没有显示出保护作用.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 营养科学 营养科学
- 自然产品化学 自然产品化学
背景情况:
- 葡萄油 (GSO) 以其潜在的健康益处而闻名.
- 调查GSO的替代来源和加工方法对于扩大其应用至关重要.
- 了解GSO的抗炎和抗氧化特性是其治疗发展的关键.
研究的目的:
- 分析从发酵葡萄种子中提取的GSO的化学成分.
- 为了评估这种替代GSO的体内抗炎和抗氧化作用.
- 为了比较发酵的GSO与商业GSO的脂肪酸概况.
主要方法:
- 气色谱 高分辨率电子电离质谱仪 (GC-HR-EIMS) 用于化学成分分析.
- 在小鼠中使用卡拉基南诱导的脚胀模型来评估抗炎活性.
- 测量血清谷氨 (GSH) 和麦隆迪 (MDA) 水平以进行抗氧化评估.
主要成果:
- 在发酵的GSO提取物中,GC-HR-EIMS确定了八个主要成分.
- 在急性炎症模型中,发酵的GSO显著减少了脚胀,与迪克洛芬雅克相似.
- 转基因植物通过降低血清GSH和MDA水平显示出抗氧化作用; 长期治疗没有益处.
结论:
- 来自发酵葡萄种子的GSO具有显著的急性抗炎和抗氧化特性.
- 这种替代GSO显示出作为治疗剂和有价值的原材料的潜力.
- 需要进一步的研究来探索发酵的GSO的治疗应用.
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