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热敏反应性基托-移植-多聚-N-异烯胺) 共聚物的合成和表征

Migle Babelyte¹, Laura Peciulyte¹, Vesta Navikaite-Snipaitiene¹

¹Department of Polymer Chemistry and Technology, Kaunas University of Technology, Radvilenu Rd. 19, 50254 Kaunas, Lithuania.

|August 12, 2023

概括

合成了热敏的奇托桑-移植-多聚 ((N-异烯胺) 共聚物. 这些材料表现出可调节的低临界溶液温度行为,显示出药物输送和组织工程应用的潜力.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物材料是一种生物材料.

背景情况:

酸盐 (CS) 是一种生物相容的聚合物,在各种领域都有潜在的应用.
热敏聚合物可以随着温度的变化而改变其溶解度,提供独特的功能.
移植共聚合物结合了不同聚合物链的特性.

研究的目的:

为了合成和表征新型热反应性奇托-移植-多聚 (N-异烯胺) (CS-g-PNIPAAm) kopo 聚合物.
为了研究共聚合物组成对热敏反应行为的影响.
评估这些共聚物在药物输送和组织工程中的潜在应用.

主要方法:

基 (CS) 和N-异烯胺 (NIPAAm) 在水溶液中的自由基聚合.
使用FTIR和1HNMR光谱学进行化学结构的表征.
通过云点,DSC和粒子大小测量评估较低的临界溶液温度 (LCST) 行为.

主要成果:

成功合成了具有不同PNIPAAm侧链含量的CS-g-PNIPAAm共聚物.
具有≥12摩尔百分比PNIPAAm侧链的共聚合物在29.0-32.7°C之间表现出LCST行为.
热敏度强度随着PNIPAAm含量增加而增加.

结论:

合成的CS-g-PNIPAAm共聚合物表现出可调节的热反应性质.
同聚合物的组成显著影响它们的LCST行为.
这些新型共聚合物有望在药物输送系统和组织工程中得到先进的应用.

关键词:

N-异烯烯胺的存在基多酸盐的使用方法热敏共聚合物是一种热敏共聚物.

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