纳米复合物凝膜基于序列互穿聚合物网络作为药物输送平台
Gabriela Toader1, Alice Ionela Podaru1,2, Aurel Diacon1,2
1Military Technical Academy "Ferdinand I", 39-49 G. Cosbuc Blvd., 050141 Bucharest, Romania.
Polymers
|August 12, 2023
概括
具有双交叉连接的新型水凝为药物输送提供了增强的机械强度. 这些纳米复合材料表现出受控的纳弗西林释放和抗菌活性,离子使大肠杆菌无活化.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 开发先进的药物输送系统对于有效的皮肤疗法至关重要.
- 水凝为药物封装和释放提供生物相容性和可调节性质.
- 纳米复合材料可以增强水凝的机械强度和功能.
研究的目的:
- 合成和描述用于皮肤药物输送的新型双交联纳米复合材料水凝.
- 为了研究这些水凝的机械特性,药物加载和释放动力学.
- 评估纳夫西林载荷水凝的抗菌活性和离子的作用.
主要方法:
- 用双重共价和离子交叉连接策略对N-乙烯基罗利的自由基光聚合.
- 纳入藻酸盐,本托尼特纳米粘土,TiO2和ZnO纳米颗粒.
- 机械测试 (拉伸和压缩),药物加载效率,以及体外药物释放研究.
- 对S. aureus,S. pyogenes和E. coli的抗菌活性测定.
主要成果:
- 形成了完全相互透的聚合物网络,具有出色的抗拉力 (1.5 MPa) 和抗压力 (12.5 MPa).
- 在纳米复合物水凝薄膜中实现了高纳弗西林加载效率 (高达30%).
- 观察了受控药物释放概况,并与数学模型相匹配.
- 纳夫西林对S. aureus和S. pyogenes表现出高至中等活性;离子与大肠杆菌失活相关.
结论:
- 双重交叉连接策略产生了强大的纳米复合材料水凝,适合皮肤药物递送平台.
- 纳米填充剂和离子的结合调节了机械性能,药物释放和抗菌有效性.
- 这些先进的水凝对有针对性的抗微生物疗法和增强药物输送应用具有前景.
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