基托桑基膜含有素,用于潜在的化品应用
Alina Sionkowska1, Katarzyna Lewandowska1, Marzanna Kurzawa2
1Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87100 Torun, Poland.
Polymers
|August 12, 2023
概括
这项研究探讨了用化品使用的酸和素基片. 开发的奇托桑-鲁丁口罩显示了改善皮肤弹性和保湿的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 化品科学 化品科学
- 聚合物化学 聚合物化学
背景情况:
- 奇托是一种多糖,具有膜形成能力,用于化品和伤口愈合应用.
- 在化品配方中,为了潜在的协同效应,加入了 hialuronic acid 和 rutin.
研究的目的:
- 为了研究含有氨酸和素的基托桑基膜的潜力,用于化品应用.
- 评估这些薄膜的结构,表面和药物释放特性.
- 评估基托桑-鲁丁面膜对皮肤特性,如弹性和保湿性的有效性.
主要方法:
- 制造基托为基础的薄膜,添加了 rutin.
- 使用富里埃转换红外光谱 (FTIR) 和原子力显微镜 (AFM) 进行了表征.
- 通过高性能液体染色学 (HPLC) 研究的鲁丁释放动力学.
- 使用Aramo TS 2装置评估的皮肤特性 (弹性,保湿性).
主要成果:
- 常规添加影响了热稳定性,并增加了基托薄膜的表面粗度,而不会改变核心结构.
- 基托桑-鲁丁面具在皮肤弹性和保湿方面表现出适度的改善.
- 在20分钟内,在pH值5.5时,rutin的最大释放发生,与生理皮肤pH值保持一致.
- 含有 hialuronic 酸的薄膜与不含的薄膜相比,表现出较低的 rutin 释放率.
结论:
- 含有素和氨酸的基酸薄膜对化品应用有前途,特别是作为保湿和增强弹性的口罩.
- 鲁丁的释放特征有利于局部应用,在皮肤相关的pH值下释放最佳.
- 进一步的研究可以优化配方以提高交付和疗效.
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