维生素D缺乏和心血管死亡率:回顾性分析"锡耶纳骨质疏松症"队列
Filippo Pirrotta1, Guido Cavati1, Christian Mingiano1
1Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Nutrients
|August 12, 2023
概括
低维生素D水平与心力衰竭和中风死亡风险增加有关. 需要进一步的研究来确认维生素D缺乏是否直接导致心血管死亡.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 维生素D对和平衡至关重要,影响骨健康.
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 心血管系统中维生素D受体 (VDR) 的存在表明维生素D在心血管疾病中的潜在作用.
研究的目的:
- 调查维生素D状况与因心力衰竭 (HF) 住院治疗之间的关联.
- 检查维生素D状况与整体和心血管死亡率之间的关系.
- 评估低25-基维生素D (25OHD) 水平对心血管结果的预测价值.
主要方法:
- 从西耶纳 (2004-2009) 的初级保健登记册中对老年男性和绝经后妇女进行了回顾性分析.
- 基于年龄的分层随机抽样.
- 调查25OHD水平与HF住院病例之间的关联,以及死亡原因.
主要成果:
- 较高比例的死亡患者表现出低的25OHD水平 (低于20 ng/mL).
- 25OHD水平低于20 ng/mL的患者表现出增加中风死亡率的趋势 (RR=2.15).
- 低25OHD水平可能预测心血管死亡率.
结论:
- 低维生素D状态,以低25OHD水平表示,与心血管死亡率增加有关.
- 这些发现表明,维生素D缺乏可能是心血管事件的危险因素.
- 需要进一步的前性研究来阐明维生素D缺乏与心血管疾病风险之间的因果关系.
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