红素,葡萄糖胺,维生素和矿物质摄入量对功能的因果作用:孟德尔的随机化研究
Jeong-Min Cho1, Jung-Hun Koh1, Seong-Geun Kim2
1Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Nutrients
|August 12, 2023
概括
常见的补充剂,如冠状素和葡萄糖胺,可能会对功能产生负面影响,降低估计的淋巴细胞过率 (eGFR). 维生素/矿物质补充剂与功能有积极的关联. 需要进一步的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 红素,葡萄糖胺和维生素/矿物质补充剂被广泛使用,但它们对功能的因果作用尚不清楚.
- 估计的膜过率 (eGFR) 是功能的一个关键指标.
研究的目的:
- 通过使用孟德尔随机化来研究氏素,葡萄糖胺和维生素/矿物质补充剂的摄入与功能之间的因果关系.
- 评估这些常见的食补充剂对eGFR的影响.
主要方法:
- 进行了对两个样本总结级别的门德尔随机化 (MR) 分析.
- 基因仪器是从全基因组协会研究中获得的,用于补充剂摄入 (冠状素,葡萄糖胺,维生素/矿物质).
- 对日志转换的eGFR的总结统计数据来自CKDGen联盟.
主要成果:
- 基因预测的ondroitin和葡萄糖胺摄入量与较低的eGFR因果相关.
- 基因预测的维生素/矿物质补充剂摄入与更高的eGFR有关.
- 验证和 pleiotropy-robust 分析证实了对冠状素和维生素/矿物质补充剂的发现.
结论:
- 红素和葡萄糖胺的摄入可能对功能产生因果,有害的影响.
- 摄入维生素/矿物质补充剂可能对功能产生因果,有益的影响.
- 临床医生应考虑ondroitin和葡萄糖胺补充剂的潜在长期脏影响.
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