关于母亲新陈代谢对子女心脏发育和功能的影响的研究进展
Zhuoran Ren1,2, Sisi Luo2,3, Jiajun Cui1,2
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200001, China.
Nutrients
|August 12, 2023
概括
怀孕期间母亲的代谢障碍会影响后代的心脏发育,增加心血管疾病的风险. 了解这些影响对于公共卫生和疾病预防至关重要.
科学领域:
- 发育生物学 发展生物学
- 心血管科学 心血管科学
- 代谢健康 代谢健康
背景情况:
- 健康和疾病的发育起源 (DOHaD) 假设将早期生活环境与以后的健康结果联系起来.
- 宫内代谢干扰可能会损害胎儿的器官生成,特别是心脏发育.
- 肥胖和糖尿病等母亲的疾病对后代的心血管健康构成风险.
研究的目的:
- 审查母亲代谢障碍对后代心脏发育和功能的影响.
- 探索母亲代谢障碍影响胎儿心脏发育的机制.
- 突出了对这些发育影响的进一步研究的需要.
主要方法:
- 文献综述和对DOHaD和心血管发育现有研究的综合.
- 对研究母亲代谢干扰及其对后代心脏状况影响的研究进行分析.
- 讨论涉及心脏发育改变的表观遗传和分子机制.
主要成果:
- 孕产妇的代谢障碍可以导致后代的结构和功能性心脏异常.
- 营养变化会影响心脏发育中的线粒体功能和基因表达.
- 表观遗传修饰 (DNA甲基化,基因质变化,微RNA) 与心脏基因调节的改变有关.
结论:
- 母亲的代谢健康显著影响后代的心血管发育和长期健康.
- 对这些影响的机制性理解是不完整的,需要进一步调查.
- 这一领域的研究对于改善公共健康和预防心血管疾病至关重要.
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