欧米茄-3脂肪酸对术后炎症反应的影响:系统性审查和元分析
Ghaith Mohsen1, Annika Stroemer2, Andreas Mayr2
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.
在腹部手术患者中,手术前的omega-3脂肪酸 (FA) 并没有显著降低术后炎症或住院时间. 由于有限的试验结果不确定的原因,需要更多的研究.
科学领域:
- 手术营养是指手术营养.
- 免疫营养 免疫营养 免疫营养
- 临床试验 临床试验
背景情况:
- 手术前的omega-3脂肪酸 (FA) 可能会减少手术后的炎症.
- 欧米茄-3脂肪酸 (eicosapentaenoic 酸 [EPA]和 docosahexaenoic 酸 [DHA]) 对腹部手术后炎症反应的影响尚不清楚.
- 这项研究调查了手术前欧米茄-3脂肪酸对术后炎症标志物 (C-反应蛋白[CRP],介质素-6[IL-6],白血计数[WBC]) 和住院时间 (LOS) 的有效性.
研究的目的:
- 为了评估手术前欧米茄-3脂肪酸对术后炎症的有效性.
- 评估欧米茄-3脂肪酸对手术后住院时间的潜在影响.
- 对腹部手术患者的omega-3FA进行随机对照试验 (RCT) 的综合证据.
主要方法:
- 在Cochrane图书馆进行了文学搜索,搜索到2022年12月之前发表的RCT.
- 包括的研究比较了手术前的omega-3FA与标准护理,安慰剂或其他免疫营养素 (不包括omega-3FA).
- 对13项RCT进行了元分析,涉及950名接受腹部手术的患者.
主要成果:
- 两组之间IL-6 (p=0.10),CRP (p=0.55) 或WBC (p=0.42) 水平没有发现显著差异.
- 住院时间 (LOS) 也没有显著影响 (p=0.2).
- 虽然观察到一些减少的炎症标志物,但这些并没有达到统计学意义.
结论:
- 在手术前服用omega-3脂肪酸免疫营养素对经过腹部手术的患者的术后炎症反应没有显著影响.
- 该研究的结果是不确定的,可能是由于试验数量有限,包括患者.
- 需要进行进一步的综合性研究,以确定omega-3脂肪酸在这种情况下的作用.
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