在加利西亚超重/肥胖和正常体重个体中遵守营养建议和肠道微生物群概况
Laura Sinisterra-Loaiza1, Patricia Alonso-Lovera1, Alejandra Cardelle-Cobas1
1Laboratorio de Higiene, Inspección y Control de Alimentos, Departamento de Química Analítica, Nutrición y Bromatología, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain.
Nutrients
|August 12, 2023
概括
食纤维和单不和脂肪酸会影响肠道微生物群的组成. 超重和肥胖个体表现出改变的肠道细菌,与正常体重,肥胖和饮食充足性相关的特定微生物.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 肥胖研究的研究.
背景情况:
- 肥胖与饮食和炎症有关,肠道微生物群可能调解这些影响.
- 了解肠道微生物群在肥胖中的作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 评估正常体重,超重和肥胖个体的饮食摄入量和肠道微生物群概况.
- 为了确定身体质量指数 (BMI),饮食和肠道微生物组成之间的关联.
主要方法:
- 纤维和单不和脂肪酸 (MUFA) 的饮食摄入量评估.
- 使用18个安普利康序列变异 (ASV) 的肠道微生物群概况.
- 统计分析包括LEfSe和相关性分析.
主要成果:
- 在BMI组中观察到纤维和MUFA摄入量的显著差异,正常体重的个体显示出更高的充足度.
- 肠道微生物群分析显示,在超重/肥胖个体中,*Anaerostipes*和*Faecalibacterium*的丰度下降,*Oscillospira*的增加.
- 在正常体重的个体中, *Roseburia faecis* 较为丰富,而 *Oscillospira* 是超重/肥胖的生物标志物.
- 充足的纤维和MUFA摄入量与特定细菌的较高丰度相关,包括*Prevotella copri*,*F. prausnitzii*,*Bacteroides caccae*和*R. faecis*.
结论:
- 肠道微生物群的组成与BMI和饮食摄入量有关.
- 特定的肠道细菌,如 * Oscillospira * 和 * Roseburia faecis * 可能分别作为肥胖和正常体重的生物标志物.
- 纤维和MUFA的饮食建议可能会影响有益的肠道微生物种群.
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