多和它们对预防神经退行性疾病和发育发展的影响
Izabela Grabska-Kobyłecka1, Piotr Szpakowski2, Aleksandra Król3
1Department of Clinical Physiology, Medical University of Lodz, Mazowiecka 6/8 Street, 92-215 Łódź, Poland.
Nutrients
|August 12, 2023
概括
植物性聚醇通过减少氧化应激和炎症,对神经退行性疾病显示出有前途. 通过纳米技术提高多的生物可用性可能会提高它们对大脑健康的治疗效果.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 营养科学 营养科学
- 生物技术是生物技术.
背景情况:
- 像帕金森氏症和阿尔茨海默氏症这样的神经退行性疾病被氧化应激和炎症加剧,导致细胞损伤.
- 饮食中的抗氧化剂,特别是植物性多,显示出延缓疾病进展和改善生活质量的潜力.
- 寿命的延长需要策略来管理与年龄有关的神经退行性疾病.
研究的目的:
- 审查关于多醇对大脑活动和功能的影响的最新研究,重点关注神经保护.
- 探索多对中枢神经系统 (CNS) 和认知功能产生影响的机制.
- 讨论聚醇生物可用性的挑战,并探索治疗应用的新策略.
主要方法:
- 综合审查现有文献,包括动物模型和临床试验.
- 对研究通过血脑屏障 (BBB) 检查聚运输及其在中枢神经系统内的稳定性的研究进行分析.
- 检查基于纳米技术的方法来增强多的输送和生物可用性.
主要成果:
- 聚醇通过增加大脑可塑性,改善认知和通过神经递质调节调节情绪来表现出神经保护作用.
- 聚醇可以增强BBB完整性,减少炎症,降低血压,改善大脑血流.
- 口服生物利用率低和BBB透率差限制了天然多的治疗功效.
结论:
- 植物多具有预防和管理神经退行性疾病的巨大潜力.
- 纳米尺度的输送系统为克服生物可用性限制和增强多向大脑的运输提供了一个有希望的策略.
- 需要进行进一步的研究,以优化聚醇结构和输送方法,以便在中枢神经系统疾病中有效治疗.
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