从人类和动物精液样本中消除细菌的策略:当前的选择和未来的替代方案
Michal Ďuračka1, Filip Benko2,3, Milan Chňapek3
1AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
Sensors (Basel, Switzerland)
|August 12, 2023
概括
细菌污染会影响精液质量和精子保存. 本综述探讨了预防污染的抗生素替代方案,重点关注人工生殖中的补充剂和先进的精子选择技术.
科学领域:
- 生殖生物学 生殖生物学
- 微生物学 微生物学
- 安德罗学与人类学
背景情况:
- 精子处理和保存的目的是保持人工生殖的精子质量.
- 细菌污染在ex vivo处理过程中对精液质量构成重大,不可预测的风险.
- 抗生素耐药性需要探索替代传统抗生素在精液保存中的使用.
研究的目的:
- 审查细菌污染 (细菌精液) 对精子活力的影响.
- 讨论与抗生素过度使用在雄性病学相关的风险.
- 总结用于防止精液加工和保存中的细菌污染的替代策略.
主要方法:
- 关于精液保存和细菌污染的现有证据的文献综述.
- 对细菌精子对精子质量影响的分析.
- 对替代抗菌策略和现代精子选择方法的评估.
主要成果:
- 细菌污染可能会对精子的活力和功能产生负面影响.
- 过度依赖抗生素有助于抗菌素耐药性.
- 替代性抗菌补充剂和物理细菌去除显示有希望.
结论:
- 有效的精液保存需要减轻细菌污染.
- 除了抗生素之外的新策略对于保持精液质量至关重要.
- 将先进的精子选择与细菌去除相结合,可以增强辅助生殖技术.
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