在糖尿病患者中评估阿迪波涅丁和TNF-α表达及其与心血管疾病的关系
Xiue Wei1, Wenhua Che2, Qiufeng Wang3
1Nursing Department, Qingdao Jiaozhou Central Hospital, Jiaozhou, Shandong 266300, China. xckwxe@126.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|August 12, 2023
概括
在2型糖尿病患者中,较低的阿迪波内克水平可能会导致心血管疾病. 在外周血液样本中,TNF-α基因促进体的表观遗传变化并不显著.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 心血管医学 心血管医学
背景情况:
- 2型糖尿病涉及胰岛素抵抗和胰腺β细胞功能障碍.
- 瘤坏死因子α (TNF-α) 是一种促炎性细胞因子,与胰岛素抵抗有关.
- 脂肪组织蛋白质阿迪波涅丁 (Adiponectin) 在血管保护中起作用.
研究的目的:
- 为了研究2型糖尿病患者的TNF-α基因促进物甲基化,有或没有心血管疾病.
- 为了比较这两组人群之间的血清阿迪波涅克度.
- 探索表观遗传修饰,阿迪波内克丁水平和糖尿病心血管并发症之间的联系.
主要方法:
- 研究包括95名2型糖尿病患者,根据血管造影结果进行分类.
- 测量了血清脂肪素,FBS,胆固醇,甘油三和高密度胆固醇.
- 使用双硫酸盐治疗,嵌套PCR和测序分析的TNF-α基因促进物甲基化.
主要成果:
- 在没有心血管疾病的糖尿病患者中,血清阿迪波涅克水平较高,尽管在统计学上不显著.
- 性别或群体之间没有发现TNF-α基因促进物甲基化中的显著差异.
- 在患有心血管疾病的患者中,阿迪波涅克水平呈现出较低的非显著趋势.
结论:
- 降低阿迪波涅丁度可能会导致糖尿病患者的大血管病变.
- 再组合阿迪波涅丁可能是糖尿病中心血管保护的潜在治疗剂.
- 与胰岛素抵抗相关的细胞因子基因的表观遗传变化可能无法在周围血液中检测到.
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