皮肤屏障功能和血清炎症因子水平的变化在使用Nd:YAG激光治疗的多颜色障碍症中
1Department of Dermatology, Sichuan Huamei Zixin Medical Beauty Hospital, Chengdu 610000, Sichuan Province, China. yuzhuo25736108@163.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|August 12, 2023
概括
与Q开关亚历山大 (Q-SA) 激光相比,酸加的伊花 (Nd:YAG) 激光治疗在高颜色障碍方面显示出更高的疗效和安全性,具有更好的皮肤屏障功能和减少炎症.
科学领域:
- 皮肤病学 皮肤病学
- 激光医学是激光医学.
- 整形外科美容手术 整形外科美容手术
背景情况:
- 超色素障碍是一种常见的皮肤疾病.
- 有各种激光治疗方法,但比较有效性和安全性数据至关重要.
- 使用Q开关亚历山大 (Q-SA) 和添加的伊特花 (Nd:YAG) 激光器进行超色素化.
研究的目的:
- 为了比较Q-SA激光与Nd:YAG激光的疗效和安全性,用于治疗多颜色障碍.
- 评估这些激光对皮肤屏障功能,色素和炎症标记物的影响.
主要方法:
- 一项比较性研究涉及86名患有多色素障碍的患者.
- 患者被分为两组:Q-SA激光治疗 (43名患者) 和Nd:YAG激光治疗 (43名患者).
- 评估了临床疗效,皮肤屏障功能 (TEWL,水含量,pH,蛋白质糖),色素,血清炎症因子 (hs-CRP,TNF-α,IL-6) 和不良反应.
主要成果:
- 与Q-SA激光相比,Nd:YAG激光组显示皮形成减少,愈合更快,TEWL减少,角层水含量改善,pH值降低,蛋白质甘油含量降低.
- 在Nd:YAG组中观察到颜色分数和颜色区域的显著减少.
- Nd:YAG激光治疗导致hs-CRP,TNF-α和IL-6的血清水平降低.
- 总有效率为Q-SA的76.74%,为Nd:YAG激光的95.35%.
- 对Q-SA的不良反应率为30.23%,对Nd:YAG激光的不良反应率为6.98%.
结论:
- Nd:YAG激光治疗,特别是使用 rhEGF 凝,在治疗多颜色障碍方面表现出更高的疗效和安全性.
- Nd:YAG激光有效地保护皮肤屏障功能,减少色素,并减轻炎症反应.
- Nd:YAG激光器提供了优越的治疗选择,副作用的发生率较低.
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