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在患有家族性高胆固醇血症的受试者中评估高密度脂蛋白结合的长非编码RNA

Roberto Scicali¹, Giosiana Bosco¹, Alessandra Scamporrino¹

¹Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

European journal of clinical investigation

|August 12, 2023

概括

由高密度脂蛋白 (HDL) 携带的长非编码RNAs (lncRNAs) 在家族高胆固醇血症 (FH) 患者中被确定. HDL-lncRNA LEXIS显示与Lp(a) 和脉冲波速度 (PWV) 的关联,表明血管损伤评估的潜力.

科学领域:

心血管研究研究心血管研究
分子生物学分子生物学
生物标志物发现发现

背景情况:

长非编码RNAs (lncRNAs) 是潜在的循环生物标志物,用于心血管疾病风险分层.
家庭高胆固醇血症 (FH) 患者代表了动脉样硬化心血管疾病的高风险人群.
在FH中研究高密度脂蛋白 (HDL) 颗粒中的lncRNA可能会提供新的见解.

研究的目的:

在FH患者中识别HDL运输的lncRNAs.
评估HDL-lncRNAs与脂蛋白的关联,特别是Lp.
评估HDL-lncRNAs与机械血管功能障碍 (PWV) 之间的关系.

主要方法:

追溯性观察性研究,对94名接受他类药物治疗的FH患者进行.
生物化学测定,高脂净化和 lncRNAs 的量化.
测量脉冲波速度 (PWV),以评估血管硬度.

主要成果:

发现HIF1A-AS2,LASER和LEXIS lncRNAs被HDL携带.
HDL-lncRNA LEXIS水平与血Lp(a) 水平显著相关 (p < .01).
具有高Lp(a) 的受试者表现出增加的PWV和显著降低的HDL-lncRNA LEXIS (折叠变化 -4.4,p < .0001).
无论是Lp(a) 和HDL-lncRNA LEXIS都是独立地与PWV相关的.

结论:

在FH患者中,特定的lncRNAs (HIF1A-AS2,LASER,LEXIS) 被HDL运输.
HDL-lncRNA LEXIS与Lp(a) 水平和脉冲波速度有显著的关系.
HDL-lncRNA LEXIS可以作为一种有价值的生物标志物,用于识别具有较大的血管损伤的FH个体.

关键词:

在 HDL 和 HDL 之间.心血管疾病的风险.家庭性高胆固醇血症脂蛋白 (a) 是一种蛋白质长长的非编码RNAs.脉冲波的速度是脉冲波的速度.

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