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通过特定的氧化铁纳米颗粒与PSMA-11片进行前列腺癌的分子MR成像:临床前研究

Farzaneh Ghorbani¹, Behzad Aminzadeh², Nahid Borji³

¹Department of Medical Physics and Radiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Journal of magnetic resonance imaging : JMRI

|August 12, 2023

概括

使用PSMA-11的向氧化铁纳米颗粒 (IONPs) 显示出用于检测前列腺癌 (PCa) 瘤的前景. 这些新的纳米分子探针为PSMA阳性PCa异种移植提供了增强的MRI对比.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
医疗成像医学成像

背景情况:

前列腺特异性膜抗原 (PSMA) 是前列腺癌 (PCa) 检测的目标,使用FDA批准的PSMA-11进行PET成像.
之前用于PSMA检测的MRI研究使用了非FDA批准的连接物与磁纳米探测器,缺乏特异性.

研究的目的:

作为特定的纳米分子探针,评估PSMA-11向氧化铁纳米颗粒 (IONPs).
通过使用MRI在PSMA阳性PCa异种移植模型中研究它们的有效性.

主要方法:

针对PSMA-11的 (TBNPs,TDNPs) 和非的 (BNPs,DNPs) IONPs被静脉注射到小鼠体内,使用PSMA+ PCa异种移植.
在注射前和后 (4小时和6小时) 进行MRI (T2-W和T2*-W).
评估信号强度 (SI),相对信号增强 (RSE),组织学和铁的分布.

主要成果:

有针对性的IONP (TBNPs,TDNPs) 与非有针对性的相比,显著减少了T2-WSI,在6小时内减少了多达78%.
在T2*-W图像上观察到TBNPs (88.6%) 和TDNPs (80.7%) 与瘤和肌肉区域之间的较强对比.
有针对性的探针允许IONPs的注射剂量减少.

结论:

针对PSMA-11的IONP (TBNP和TDNP) 是通过MRI检测PSMA阳性PCa的新型纳米分子探针.
有针对性的纳米探针可以减少非有针对性的IONP的剂量,提高效率.

关键词:

在PSMA上,PSMA可以在PSMA上进行交易.铁氧化物纳米粒子 (IONPs) 是一种磁共振成像技术的使用分子成像分子成像技术前列腺癌是前列腺癌.

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