视网膜动脉封闭后的心血管风险的他类药物治疗:一个历史的队列研究
Joonsang Yoo1, Jimin Jeon1, Joo Youn Shin2
1Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, 363 Dongbaekjukjeon-Daero, Giheung-Gu, Yongin-Si, Gyeonggi-Do, 16995, Republic of Korea.
Journal of epidemiology and global health
|August 12, 2023
概括
视网膜动脉封闭 (RAO) 后的他类药物治疗显著降低了随后心血管事件的风险. 长期使用他类药物为RAO患者提供了更大的保护.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 视网膜动脉封闭 (RAO) 会导致急性视力丧失,并增加心血管事件的风险.
- 在RAO患者中,将他类药物的使用与心血管事件预防联系起来的证据有限.
- 这项研究调查了RAO患者的他类药物治疗和心血管结果之间的关联.
研究的目的:
- 为了确定RAO患者的他类药物治疗是否与心血管事件的风险降低有关.
- 为了评估他类药物持续时间对RAO人群心血管风险的影响.
主要方法:
- 使用韩国全国医疗保险索赔数据进行了嵌套病例控制分析的历史队列研究.
- 包括新诊断的RAO患者,没有先前的心血管事件 (2008-2020年).
- 病例 (心血管事件) 与对照组 (没有事件) 根据性别,年龄,并发症和随访时间相匹配 1:2.
主要成果:
- 在13843名RAO患者中,1030人在平均6.4年的随访期间经历了心血管事件.
- 经RAO后的静止剂治疗与显著降低心血管事件风险有关 (aOR,0.637;P < 0.001).
- 长时间的他类药物暴露与进一步降低心血管风险相关.
结论:
- 立方体治疗,特别是长期使用,与新诊断RAO的患者未来心血管事件的风险降低有关.
- 这些发现支持在RAO患者中使用他类药物进行二次预防.
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