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在封闭的小动物中评估左心室体积和功能F-FDG PET/CT成像:对三种商用软件工具进行比较研究

Mathias J Zacherl¹, Agus Simenhandra^2,3, Magdalena Lindner¹

¹Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377, Munich, Germany.

EJNMMI research

|August 12, 2023

概括

三种软件工具 (PMOD,MIM,QGS) 可以在小鼠的封闭式18F-FDG PET/CT成像中评估心脏体积. 然而,心脏功能分析的差异意味着这些工具在小鼠研究中不能互换使用.

科学领域:

核医学是一种核医学.
心血管成像 - 心血管成像
小动物研究小动物研究

背景情况:

门式正电子发射断层扫描 (PET) 成像软件工具使用不同的算法来分析心脏功能.
之前的研究表明,不同的软件工具在人类研究中可能不会产生可互换的结果.
这项研究比较左心室参数,这些参数来自于使用三个商业软件包:PMOD,MIM和QGS的小鼠的封闭式18F-FDG PET/CT成像.

研究的目的:

评估和比较PMOD,MIM和QGS软件在小鼠左心室体积和功能评估中的性能,使用封闭的18F-FDG PET/CT.
确定这些软件工具是否为小鼠心脏分析提供一致和可互换的结果.

主要方法:

在麻醉下,健康小鼠接受了ECG-gated 18F-FDG PET/CT成像.
重建的PET图像使用PMOD,MIM和QGS软件进行分析.
用布兰德-阿尔特曼分析量化和比较心脏体积 (终端透缩体积 [EDV],终端静脉体积 [ESV]) 和功能 (中风体积 [SV],射出分数 [EF]).

主要成果:

心脏体积 (EDV,ESV,SV) 在PMOD,MIM和QGS之间显示出良好的相关性.
然而,喷射分数 (EF) 在软件包之间显示出不良的相关性.
类间和类内相关系数超过0.9,表明每个软件中的可重复性,用于体积和功能评估.

结论:

PMOD,MIM和QGS都是可行的,用于评估小动物封闭18F-FDG PET/CT成像中的心脏体积.
心脏功能分析中与软件相关的显著差异,特别是对于射出分数,排除了它们在小鼠研究中的可互换使用.
在临床前研究中选择用于定量心脏分析的软件时,研究人员应该意识到这些差异.

关键词:

在18F-FDG中.心脏的功能心脏的功能图像处理软件图像处理软件在这里,MIMIM就是MIM.在PMOD中使用PMOD.在QGS中,QGS是QGS.小动物正子辐射断层扫描.

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