肥胖和男性不孕不育问题
Devini Ameratunga1, Alpha Gebeh2, Akwasi Amoako3
1Mayne Academy of Obstetrics and Gynecology, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Obstetrics and Gynecology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; Queensland Fertility Group (QFG), Brisbane, Australia.
Best practice & research. Clinical obstetrics & gynaecology
|August 12, 2023
概括
肥胖会对男性生育能力产生负面影响,由于复杂的因素,研究结果各不相同. 有效的肥胖治疗显示出改善生殖健康结果的希望.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 安德罗学与人类学
- 肥胖医学 肥胖医学
背景情况:
- 全球肥胖率的上升影响着整体健康,并且越来越多地与生殖健康问题有关.
- 肥胖被认为是男性不孕症的一个因素,尽管其对精液参数和生育结果的确切影响仍在争论中.
- 研究中的矛盾发现可能源于激素,遗传,表观遗传和氧化压力因素的复杂相互作用,这些因素影响男性生殖功能.
研究的目的:
- 审查目前对肥胖对男性生殖健康和生育能力的影响的理解.
- 探索研究结果中观察到的争议背后的多因素病因.
- 讨论对辅助生殖和后代健康的影响,并突出潜在的治疗策略.
主要方法:
- 关于研究肥胖,精液参数和男性生育能力之间的关系的文献综述.
- 分析复杂的病理生理学,包括荷尔蒙失衡,遗传/表观遗传因素和氧化应激.
- 检查肥胖的治疗方法及其对生殖结果的潜在影响.
主要成果:
- 有证据表明,体重指数增加和男性生育能力下降之间存在联系,但研究结果不一致.
- 病理生理学涉及影响性腺激素,末端器官和细胞功能 (如氧化应激) 的复杂相互作用.
- 肥胖的影响可以导致辅助生殖技术的各种结果,并影响后代的健康.
结论:
- 肥胖对男性生育能力构成了复杂的挑战,有各种各样的因素和不一致的研究结果.
- 了解多因素性质对于解释研究结果和指导临床实践至关重要.
- 有效的肥胖管理,包括新兴的医疗疗法,有可能改善男性生殖健康和辅助生殖结果.
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