VirhostlncR:一个全面的数据库来探索病毒感染中的 lncRNA 和它们的目标
Arun Kumar Sumaithangi Thatai1, Shruthi Ammankallu1, Rex Devasahayam Arokia Balaya2
1Centre for Systems Biology and Molecular Medicine (CSBMM), Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, 575 018, Karnataka, India.
Computers in biology and medicine
|August 12, 2023
概括
长非编码RNA (lncRNAs) 在病毒感染中起着关键作用. VirhostlncR资源识别了2803个由病毒调节的lncRNA,有助于对这些关键感染调节者的功能分析.
科学领域:
- 分子生物学分子生物学
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 长非编码RNAs (lncRNAs) 是具有很大程度上未定义功能的调节性RNA分子.
- 新出现的证据强调了 lncRNAs 在病毒感染病原发生过程中的关键作用.
- 了解lncRNA的参与对于开发新型抗病毒策略至关重要.
研究的目的:
- 编制和呈现一个全面的资源病毒调节 lncRNAs.
- 为了识别被多个病毒扰乱的标志性 lncRNAs.
- 促进对病毒感染中的lncRNA功能和调节机制的研究.
主要方法:
- 策划了一个数据库 (VirhostlncR) 的2803 lncRNAs调节通过33个病毒菌株跨越各种哺乳动物细胞.
- 综合数据包括病毒菌株,感染状况,宿主细胞和lncRNA表达变化.
- 分析了病毒蛋白,人类转录因子和lncRNA调节之间的相互作用.
主要成果:
- VirhostlncR数据库提供了有关病毒调节的lncRNAs的详细信息.
- 确定了150个lncRNAs,包括DANCR,MALAT1,MEG3,NEAT1和PVT1,受到两个或两个以上病毒的影响.
- 证明病毒可以通过多个蛋白质复合体通过转录调节lncRNAs.
结论:
- 病毒宿主lncR 作为一个有价值的平台,用于调查 lncRNA 在病毒感染中的作用.
- 已识别的特征 lncRNAs 可以优先进行功能研究.
- 本资源支持在病毒病原发生过程中分析非编码RNA介导的调节网络.
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