标准化急性髓性白血病分类系统:国际专家小组的观点
Rory M Shallis1, Naval Daver2, Jessica K Altman3
1Department of Internal Medicine, Section of Hematology, Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA.
The Lancet. Haematology
|August 12, 2023
概括
两种急性髓性白血病分类系统创造了诊断挑战. 协调这些系统是迫切需要的一致的病人护理和研究.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 目前,急性髓性白血病 (AML) 存在两个不同的分类系统:世界卫生组织 (WHO) 系统和国际共识分类 (ICC) 系统从2022年开始.
- 两种系统都旨在基于基因组的定义和减轻爆发数量的重视,但在AML的诊断标准方面仍然存在重大分歧.
研究的目的:
- 审查世卫组织和ICC AML分类系统的优缺点.
- 突出这两种系统在临床实践,研究和监管过程中的共存所带来的挑战.
- 提出一个路线图,以协调不同的反洗钱分类系统.
主要方法:
- 世界卫生组织和国际刑事法院AML分类系统的比较分析.
- 审查系统之间的差异对临床,研究和监管的影响.
- 讨论系统协调的潜在策略.
主要成果:
- 世卫组织和ICC系统在AML诊断方面的分歧给医疗保健提供者带来了根本性的问题.
- 存在双重分类系统使患者诊断,沟通,管理,临床试验资格,反应评估和药物开发变得复杂.
- 目前的情况给患者,临床医生,血液病理学家,研究人员和监管机构带来了不必要的挑战.
结论:
- 在AML分类系统的分歧对一致的患者护理和该领域的进步构成重大威胁.
- 世界卫生组织和ICC分类系统的紧急协调是必要的.
- 提出了一份明确的路线图,以协调这些差异,并建立一个统一的AML分类方法.
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