尼亚摄入量与抑郁症之间的关联:全国性的横截面研究
Leiyong Zhao1, Shanshan Guo1, Jie Yang1
1Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Journal of affective disorders
|August 12, 2023
概括
饮食中酸的摄入量显示了与抑郁症的U形关联. 最佳的氨酸水平可能会降低抑郁症风险,而非常低和非常高的摄入量都与风险增加有关.
科学领域:
- 营养精神病学 营养精神病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 饮食因素越来越多地与心理健康有关.
- 素 (维生素B3) 摄入量与抑郁症状之间的具体关系尚不清楚.
- 这项研究调查了素消费与抑郁症之间的关联.
研究的目的:
- 在美国一般人群中探索素摄入量和抑郁症状之间的关联.
- 确定该协会中潜在的非线性关系和拐点.
- 为了检查氨酸与抑郁症关系的种群差异.
主要方法:
- 使用单变量和多变量逻辑回归分析.
- 采用了通用的添加模型,并使用了平滑的合曲线来检测非线性.
- 使用递归算法计算了拐点,并对人口差异进行了分层分析.
主要成果:
- 没有发现统计学意义上的线性关联 (OR:0.94,95%CI:0.87-1.01).
- 确定了尼亚摄入量和抑郁症之间的U形关系,转折点为26.6 mg/d.
- 较低的氨酸摄入量 (在拐点之前) 显示出保护作用 (OR:0.77,95% CI:0.68-0.87),而较高的摄入量 (在拐点之后) 与风险增加有关 (OR:1.13,95% CI:1.01-1.28).
结论:
- 在美国人口中,氨酸摄入量和抑郁症之间存在显著的U形关联.
- 这种模式在特定的人口群体中是一致的,包括男性,墨西哥裔美国人,白人,年轻成年人 (<40岁),以及BMI<30.0的人.
- 这些发现表明酸摄入量对于抑郁症状风险的潜在最佳范围.
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