通过NF-κB调节和对系统IL-17A的上调调节,三种细菌levans的 prebiottic介导的胃保护潜力
Shireen A A Saleh1, Heba Shawky2, Asmaa Ezzat1
1Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries and Drug Research Institute, National Research Centre, Dokki 12622, Cairo, Egypt.
细菌levans通过减少和炎症,显示出显著的胃保护作用. 它们的益生菌活性与抗氧化和抗炎潜力相关,为胃保护提供了一种新的方法.
科学领域:
- 微生物学和免疫学
- 药理学和毒理学 药理学和毒理学
背景情况:
- 细菌levans是多糖,具有潜在的健康益处.
- 它们的胃保护机制,特别是与益生菌和抗炎作用相关,需要进一步研究.
研究的目的:
- 调查细菌levans的胃保护作用及其与益生菌相关的抗炎和抗氧化潜力之间的相关性.
- 在体内胃模型中评估三种细菌levans (LevAE,LevP,LevZ) 的安全性和有效性.
主要方法:
- 使用TLC,NMR和FTIR,Levans被准备,净化和表征.
- 在LPS刺激的RAW 264.7细胞系中评估了抗炎性质.
- 在Wistar大鼠中使用乙醇诱导的胃模型评估了胃保护和安全潜力.
主要成果:
- 这三种levans都显著减少了胃的数量和严重程度.
- LevAE和LevZ表现出最高的胃保护作用.
- LevZ表现出优异的抗氧化活性 (谷氨,甲酶,MDA),而LevAE和LevZ显示出强大的抗炎作用 (IL-1β,TNF-α,COX2,PGE2,NF-κB).
- 莱万斯是安全的,表现出抗脂血性质,并具有与抗效应相关的益生菌活性.
结论:
- 细菌levans具有显著的胃保护,抗氧化和抗炎性质.
- 这些levans的胃保护性活性是由益生菌相关的全身免疫调节介导的.
- 细菌levans代表了胃保护的有前途的治疗策略.
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