开发mabuterol透皮贴片:对改善贴片稳定性的离子对的分子机制研究
Liuyang Wang1, Yu Pang1, Qi Zheng1
1School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
International journal of pharmaceutics
|August 12, 2023
概括
这项研究使用离子对策略开发了一种稳定的马布醇 (MAB) 通过皮肤贴片用于喘治疗. 优化的MAB-乳酸补丁显示了增强的热稳定性和改善的药物保留.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 马布醇 (MAB) 呈现热不稳定性,阻碍其在通过皮肤贴片中的使用.
- 离子配对是一种提高药物稳定性和输送的策略.
- 透皮药物输送系统对喘等慢性疾病具有优势.
研究的目的:
- 使用离子对策略制备稳定的马布醇 (MAB) 通过皮肤贴片.
- 为了优化配方因素,包括反离子和压力敏感粘合剂 (PSA).
- 阐明离子对策略稳定效应背后的分子机制.
主要方法:
- 使用乳酸 (LA) 的离子对形成和用基粘合剂 (AAOH) 的配方.
- 通过稳定性和体外皮肤透性研究进行优化.
- 使用TGA,拉曼,FT-IR,NMR,XPS和分子建模进行表征.
主要成果:
- 优化的MAB-LA贴片显示了增强的热稳定性 (TGA 213.11°C) 和改善的药物保留 (15%高于12个月后).
- 分子建模和光谱分析证实了强大的离子和键,有助于MAB的稳定性.
- MAB-LA和AAOH PSA之间的相互作用进一步增强了药物的稳定性和受控的扩散.
结论:
- 离子对策略有效地稳定了MAB在通过皮肤贴片的配方中.
- 开发的MAB贴片为喘治疗提供了一种有前途的方法,其稳定性和分娩能力得到了改善.
- 这项研究为应用离子配对来增强皮肤外贴的稳定性提供了有价值的参考.
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