适度可以缓解成年人和引起的肺功能障碍:一项基于人口的研究
Heze Fan1, Ying Xiong1, Yuzhi Huang1
1Cardiovascular Department, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an 710061, China.
The Science of the total environment
|August 12, 2023
概括
(Se) 可能会保护肺功能免受 (Cd) 和 (Pb) 等有毒重金属的影响. 在这项流行病学研究中,中等水平的Se减轻了有害影响,但高度的Se强化了毒性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肺部医学 肺部医学
背景情况:
- 像 (Cd) 和 (Pb) 这样的重金属是众所周知的肺毒性物质.
- (Se) 在动物模型中表现出对重金属的对抗作用.
- 缺乏关于Se对Cd和Pb引起的肺毒性的保护作用的流行病学证据.
研究的目的:
- 调查血液中Cd,Pb和Se度之间的关联.
- 评估Cd和Pb对肺功能的影响 (FVC,FEV1,FEV1/FVC).
- 为了确定Se是否会改变人群中Cd和Pb的肺毒性.
主要方法:
- 利用了2011-2012年国家健康和营养检查调查 (NHANES) 的数据.
- 测量血液中的Cd,Pb和Se水平使用诱导合血质谱法.
- 采用线性回归,受限立方线和基于量子的g计算 (qgcomp) 进行统计分析.
主要成果:
- 增加的Cd和Pb水平与FEV1,FVC和FEV1/FVC的下降显著相关.
- 在Se水平和肺功能之间观察到一个反转的U形关联.
- 适度的Se水平减轻了Cd和Pb对肺功能的不良影响,而非常高的Se水平则强化了毒性.
结论:
- 血液Cd和Pb与成人肺功能减弱有关.
- 适度的含量可以提供保护,防止重金属引起的肺损伤.
- 高度可能会加剧重金属毒性,需要进一步调查.
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