相关实验视频

Updated: Jul 19, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

扩展谱β-乳酸酶产生肠杆菌 (ESBL-PE) 在尼泊尔的流行:系统性审查和元分析

Christina Khadka¹, Manita Shyaula¹, Gopiram Syangtan²

¹Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

The Science of the total environment

|August 12, 2023

概括

2011年至2021年,尼泊尔的扩展谱β-乳糖酶产生性肠杆菌 (ESBL-PE) 的患病率显著增加. 这些ESBL-PE分离物与多药性耐药性 (MDR) 有着强烈的相关性,对公众健康构成重大威胁.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

扩展光谱β-乳糖酶产生肠杆菌 (ESBL-PE) 对有效的抗生素治疗构成越来越大的威胁.
了解ESBL-PE的流行和耐药性模式对于公共卫生战略至关重要.

研究的目的:

量化估计2011年至2021年间尼泊尔ESBL-PE的流行程度.
确定ESBL-PE与多药性耐药性 (MDR) 之间的相关性.

主要方法:

基于社区和临床研究的系统审查和元分析.
遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
使用纽卡斯尔-太华尺度进行质量评估.

主要成果:

在Enterobacteriaceae中ESBL生产者的整体综合流行率为29% (26-32%),具有很高的异质性.
患病率从2011年的18.7%增加到2021年的29.5%.
在ESBL生产和MDR之间发现了强烈的正相关性 (r=0.98).

结论:

在过去的十年里,尼泊尔的ESBL-PE患病率大幅增加.
ESBL-PE分离体对各种抗生素,包括β-乳糖胺,具有高MDR.
有效的感染控制计划对于打击抗生素耐药性增加至关重要.

关键词:

这就是ESBL.它们是Enterobacteriaceae的细菌.感染控制程序的感染控制程序.进行元分析分析.多种药物耐药性多种药物耐药性尼泊尔尼泊尔尼泊尔尼泊尔尼泊尔系统性审查系统性审查

更多相关视频

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

相关概念视频

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Acute Pyelonephritis II: Diagnostic Studies and Management

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...