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Updated: Jul 19, 2025

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells

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Published on: December 17, 2015

对Porphyromonas gingivalis携带的prophages进行系统分析

B L Gu¹, Y She², G K Pei¹

¹Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital (College of Clinical Medicine) of Henan University of Science and Technology, Jianxi, Luoyang, Henan 471003, China.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

|August 12, 2023

概括

Porphyromonas gingivalis 菌株携带着 prophages,其中许多含有抗生素耐药性基因 (ARGs). 这些prophages可能有助于ARGs的传播和P. gingivalis.的致病性演变.

科学领域:

微生物学微生物学
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

Porphyromonas gingivalis 是牙周炎的一个关键病原体.
前体,病毒DNA集成到细菌基因组,可以影响细菌的特征.

研究的目的:

为了研究P. gingivalis.中的prophages.
为了在这些基因中识别抗生素耐药性基因 (ARG) 和毒性因子 (VF).

主要方法:

收集了90个P. gingivalis整个基因组序列.
曾经使用过Prophage Hunter软件来预测菌.
使用综合抗生素研究数据库 (CARD) 分析了ARG.
使用病毒感染因子数据库 (VFDB) 识别的病毒感染因子.

主要成果:

在24/90 P. gingivalis菌株 (26.7%) 中鉴定了69个prophages.
在17个活跃的菌体中发现了188个ARG,使其对多种表型产生抗性.
在三个活跃的prophages中检测到4个VF,可能会转移到其他细菌.
前体基因构成了P. gingivalis基因组中的很小一部分 (0.5%-6.7%).

结论:

在P. gingivalis菌株的很大一部分中,有食原体存在.
P. gingivalis prophages携带许多ARG,这表明它在抗生素耐药性传播中的作用.
病毒性基因很少被这些prophages携带.
前体可能会影响P. gingivalis病原性和抗生素耐药性的演变.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.葡萄牙牙牙病 Porphyromonas gingivalis 这种虫子是预体细胞的前体细胞.病毒性基因是病毒性基因.

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