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Updated: Jul 19, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
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The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

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开发超粒子技术,用于通过圆窗介导向尾管输入药物.

Niliksha Gunewardene1, Yutian Ma2, Patrick Lam3

  • 1Bionics Institute, East Melbourne, Victoria 3002, Australia; Department of Medical Bionics, The University of Melbourne, Fitzroy, Victoria 3065, Australia.

Journal of controlled release : official journal of the Controlled Release Society
|August 12, 2023
PubMed
概括

超粒子 (SPs) 显示出持续传递神经营养素3 (NT3) 通过圆窗膜 (RWM) 治疗听力损失的希望. 涂层SPs改善了尾中的药物保留,可检测到8周的水平.

关键词:
药物输送是药物输送的过程.听力损失 听力损失神经营养素-3是一种神经营养素.药理动力学 药理动力学超粒子是一种超粒子.

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The Cochlea01:13

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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