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Updated: Jul 19, 2025

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
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考虑肝脏代谢稳定性数据中与供应商相关的差异,以优化在药物发现中早期的ADME查

Pranav Shah1, Elias C Padilha1, Rintaro Kato1

  • 1National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Drive, Rockville, MD 20850, United States.

SLAS discovery : advancing life sciences R & D
|August 12, 2023
PubMed
概括

鼠肝显微体 (RLM) 的供应商差异可能会影响药物的代谢稳定性评估. 这项研究强调需要考虑RLM源来获得可靠的体外和体内药物相关性,防止误导性的早期药物发现结果.

关键词:
康宁-格恩特斯特的情况肝脏显微体 肝脏显微体代谢稳定性 代谢稳定性供应商之间的差异是不同的.异种技术 (Xenotech) 是一种新技术.

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