核酸输送和癌症治疗的氧反应性聚合物纳米粒子:进展,机遇和挑战
Lei Xu1,2,3, Yuan Cao1,2,3, Ya Xu1,2,3
1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.
Macromolecular bioscience
|August 12, 2023
概括
反氧反应纳米颗粒在癌症治疗中提供核酸药物的有希望的策略. 这些纳米颗粒被设计为在癌细胞内有效释放它们的治疗有效载荷,克服了传递挑战.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 癌症进展与瘤基因激活和瘤抑制基因丧失有关.
- 核酸药物 (siRNA,mRNA,DNA) 对癌症治疗有希望,但面临着交付挑战.
- 细胞吸收不足和核酶敏感性阻碍了核酸药物的有效性.
研究的目的:
- 审查用于癌症治疗中的核酸输送的氧化还原反应纳米粒子.
- 总结最近在设计利用癌症异常氧化还原状态的纳米颗粒方面的进展.
- 讨论纳米粒子介导核酸输送的未来方向和临床翻译挑战.
主要方法:
- 介绍关键的基因和信号通路,涉及到癌症的异常氧化还原状态.
- 核酸输送的氧化还原反应纳米粒子的最新发展的系统总结.
- 对触发细胞内药物释放的纳米粒子设计原则的讨论.
主要成果:
- 响应瘤微环境的氧化还原状态的聚合物纳米粒子是有效的输送载体.
- 反氧反应的纳米颗粒促进核酸药物的快速细胞内释放.
- 这些系统提高了癌症相关基因调节的特异性和效率.
结论:
- 反氧化反应的纳米颗粒代表了核酸在癌症中药物输送的重大进步.
- 利用癌细胞的氧化还原环境提供了一个有针对性的治疗策略.
- 需要进一步的研究来解决临床翻译的挑战,以便广泛应用.
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