大肠炎
Catherine Le Berre1, Sailish Honap2, Laurent Peyrin-Biroulet3
1Institut des Maladies de l'Appareil Digestif, Hépato-Gastro-Entérologie et Assistance Nutritionnelle, Inserm CIC 1413, Inserm UMR 1235, Nantes Université, CHU Nantes, Nantes, France.
Lancet (London, England)
|August 12, 2023
概括
性结肠炎是一种慢性肠道炎症, 新的治疗方法旨在缓解和内镜治疗, 但有些患者仍然需要手术, 这凸显了精准医学的需要.
科学领域:
- 胃肠病学
- 免疫学
- 内部医学
背景情况:
- 性结肠炎 (UC) 是一种影响结肠的慢性炎症性疾病,其全球流行率正在上升.
- 结核病原包括遗传倾向,环境因素,肠道屏障功能障碍,微生物群变化和免疫失调.
- 诊断依赖于临床,生物,内镜和组织学评估.
研究的目的:
- 概述目前对性结肠炎的理解和治疗.
- 审查诱导和维持UC缓解的治疗策略.
- 探索UC治疗的未来方向,强调精确和个性化医疗.
主要方法:
- 关于性结肠炎的最新医学文献的审查.
- 对UC的诊断标准和治疗方式的分析.
- 讨论新兴的治疗目标和方法.
主要成果:
- 目前的治疗方法包括5-氨基酸药物,皮质类固醇,氨酸,生物药物和小分子治疗UC.
- 尽管治疗方面取得了进展,10-20%的UC患者由于耐火性疾病而需要进行直肠切除术.
- 扩大治疗选择提供了希望, 但实现长期缓解和预防残疾仍然存在挑战.
结论:
- 有效治疗性结肠炎需要通过正常化生物标志物和内镜治疗诱导快速的临床反应并维持长期缓解.
- 结合疗法,精准医学和个性化方法可以克服目前性结肠炎的治疗局限性.
- 持续研究UC病变和新疗法对于改善患者的治疗结果至关重要.
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