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高度前列腺癌的标准化PSMA-PET成像

R Seifert¹, A Gafita², T Telli¹

¹Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.

Seminars in nuclear medicine

|August 12, 2023

概括

前列腺特异性膜抗原 (PSMA) -PET/CT成像对于晚期前列腺癌至关重要. 像PROMISE和PSMA-RADS这样的标准化框架有助于报告发现,PSMA-PET瘤体积作为生物标志物显示出有希望.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学就是核医学.

背景情况:

先进的前列腺癌成像需要标准化的方法来选择治疗和评估疗效.
前列腺特异性膜抗原 (PSMA) -PET/CT已经成为高级前列腺癌成像的标准.
像PROMISE和PSMA-RADS这样的标准化报告框架对于一致的PSMA-PET解释至关重要.

研究的目的:

讨论最近关于PSMA-PET衍生瘤体积作为预后结果生物标志物的证据.
审查和讨论PSMA-PET成像中报告和响应评估的既定和新兴框架.
突出PSMA-PET生物标志物在患者管理中的临床相关性.

主要方法:

对PSMA-PET衍生瘤体积及其预后价值的最新证据的审查.
关于标准化报告框架的讨论:PROMISE和PSMA-RADS.
响应评估框架的解释和讨论:PSMA-PET进步 (PPP) 标准和PSMA (RECIP) 的响应评估标准.

主要成果:

来自PSMA-PET的瘤体积,特别是当量化每个器官系统 (PROMISE框架) 时,是预测结果的有价值生物标志物.
在PSMA-PET衍生的瘤体积的变化显示出评估治疗反应的希望.
存在局限性,包括由于PSMA表达率下降和适合有限疾病的潜在误解.

结论:

标准化框架对于客观报告和响应评估在晚期前列腺癌PSMA-PET成像中至关重要.
来自PSMA-PET的瘤体积及其变化是临床管理和预测结果的重要生物标志物.
像PPP和RECIP这样的新兴标准为不同疾病表型提供了最佳的响应评估.

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