再见,再见,线性,再见:在随机环境中量化线性CRN的平均值
Mark Sinzger-D'Angelo1,2, Sofia Startceva1,2, Heinz Koeppl3,4
1Electrical Engineering and Information Technology, Technische Universität Darmstadt, Darmstadt, Germany.
Journal of mathematical biology
|August 12, 2023
概括
由内在和外在因素引起的细胞异质性,即使在批量数据中也会影响平均表达水平. 我们的研究为马尔科夫环境中的线性反应系统中这种效应提供了分析表达.
科学领域:
- 系统生物学 系统生物学
- 生物物理学的生物物理.
- 计算生物学 计算生物学
背景情况:
- 细胞过程表现出固有的静态性和环境异质性,导致人口变化.
- 虽然单细胞测量剖析异质性,但批量数据 (平均表达水平) 仍然普遍存在.
- 异质性对批量测量的影响往往是隐藏的,特别是通过与环境因素的相互作用.
研究的目的:
- 严格分析细胞异质性如何影响批量数据中的平均表达水平.
- 开发一个分析框架,以了解外部噪声对蜂系统的影响.
- 在异质环境中量化从准稳定状态假设的偏差.
主要方法:
- 在离散状态马尔科夫环境中嵌入线性反应系统的建模.
- 为系统的静止平均值推导一个分析表达式.
- 分析静止平均值对反应速率和环境参数的依赖.
主要成果:
- 静止平均值的衍生分析表达式包含反应速率常数和马尔科夫环境属性 (发电机,静止分布).
- 证明环境异质性显著影响静态平均表达水平.
- 展示了当嵌入式系统动态比环境变化更快时,与准稳定状态 (Q.SS) 近似的偏差.
结论:
- 异质性的指纹可以在批量数据中检测到,通过与环境的相互作用影响平均表达水平.
- 分析模型提供了对蜂系统外部噪声效应的定量理解.
- 对于与异质环境相结合的快速细胞系统,准稳态近似可能不足.
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