探索阿联的骨关节炎患者治疗决策:基于适应性选择的横截面联合研究
Basem Al-Omari1, Joviana Farhat2, Mumtaz Khan2,3
1Department of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates. basem.alomari@ku.ac.ae.
BMC public health
|August 12, 2023
概括
骨关节炎患者优先考虑避免药物的副作用而不是益处. 他们更喜欢处方治疗,其中"服用药物的方法"显示出患者最多的变化.
科学领域:
- 药物经济学 药物经济学
- 患者为中心的护理
- 健康研究成果研究结果
背景情况:
- 骨关节炎 (OA) 在全球范围内对健康造成重大负担.
- 了解患者的偏好对于有效的药物治疗选择至关重要.
- 之前的研究已经探索了治疗偏好,但特定的患者优先级需要进一步调查.
研究的目的:
- 评估骨关节炎患者对药物治疗的偏好.
- 确定各种治疗属性的相对重要性,包括益处和副作用.
- 用适应性基于选择的联合 (ACBC) 方法进行偏好评估.
主要方法:
- 一项基于自适应选择的联合 (ACBC) 研究是由阿联的患者和公共参与 (PPI) 组设计的.
- 使用Sawtooth软件开发了一个包含10个属性和34个级别的问卷.
- 数据使用层次贝叶斯学 (HB) 方法进行分析,并通过SPSS中的Z分数进行标准化.
主要成果:
- 共有1030名OA患者参与,主要是女性 (83.4%) 和50岁以上 (83.6%).
- 与药物的益处相比,避免药物的副作用 (66%的相对重要性) 是最重要的 (6%).
- "服用药物的方式"属性显示出最大的变化 (70%),而特定的副作用 (胃潰瘍,成,器官功能障碍,心血管风险) 则有18-21%的变化.
结论:
- 骨关节炎患者始终优先考虑避免药物副作用,与其他种族群体保持一致.
- 尽管"药物服用方式"的重要性较低,但患者特异性变化最高.
- 患者表明他们更喜欢处方药,而不是在网上购买或非处方药的选择.
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