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血液和生化炎症标志物随体质增加而增加,在青少年中具有积极的相关性
Robert P Hoffman1, Chack-Yung Yu2
1Division of Endocrinology, Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. Robert.Hoffman@Nationwidechildrens.org.
Pediatric research
|August 12, 2023
概括
在健康的青少年中,炎症标志物随着体重的增加而增加. 中性粒细胞与淋巴细胞的比率 (NLR) 表明炎症和补充水平增加,无论肥胖程度如何.
科学领域:
- 儿科炎症研究儿童炎症的研究.
- 青少年的心脏代谢风险因素
- 动脉样硬化的生物标志物
背景情况:
- 动脉样硬化是一种慢性炎症性疾病,从童年开始.
- 了解早期的炎症标志物对于长期的心血管健康至关重要.
- 这项研究调查了青少年早期炎症的早期指标.
研究的目的:
- 探索青少年血液炎症标志物和身体质量之间的关系.
- 检查这些标记物与生化炎症标记物的关联.
- 评估与心脏代谢风险因素的联系.
主要方法:
- 招募了75名健康的青少年 (12-18岁).
- 测量体质指数百分位数 (BMI%),中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),全免疫炎症值 (PIV),脂质,增强指数,反应性高血压,炎症标志物 (IL-6,CRP),补充因子 (C3,C3a,C4,C4a,C5a) 和胰岛素敏感性.
- 使用口服葡萄糖耐受性测试来测试胰岛素分泌和敏感性 (马苏达指数,处置指数).
主要成果:
- NLR,PLR,PIV和CRP与BMI%正相关.
- NLR,PLR和PIV显示了积极的相互关联.
- NLR与反应性高血压相关,当BMI%被包括在内时,这种关联会消失.
- 即使考虑到BMI%,NLR也显示出与C3a,C4,CRP和IL-6的正相关性.
结论:
- 在健康的青少年中,血液炎症标志物随体质增加而增加.
- 中性粒细胞与淋巴细胞的比率与补充和炎症标志物的升高有关,独立于肥胖.
- 在这个队列中,没有发现血液炎症标志物与心脏代谢风险标志物有关.
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