减少在自闭症谱线上的大脑连接,通过共同双胞胎设计控制家族混
Janina Neufeld1, Simon Maier2, Mirian Revers3
1Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health & Stockholm Health Care Services, Karolinska Institutet & Region Stockholm, Stockholm, Sweden. janina.neufeld@ki.se.
Scientific reports
|August 12, 2023
概括
自闭症与大脑连接性降低有关. 临床自闭症显示脑干-状连接下降,而自闭症特征与涉及海马体和状环的大脑网络中较弱的连接相关.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 自闭症谱系障碍 (ASD) 研究已经不一致地确定了大脑连接性的改变.
- 以前的研究往往侧重于有限的联系,可能会导致结果偏见.
研究的目的:
- 为了更公正地评估与临床自闭症和自闭症特征有关的白质连接性.
- 调查遗传和环境因素在这些连接差异中的作用.
主要方法:
- 在87对双胞胎 (174个人) 中采用了全球光纤跟踪和双胞胎内对设计.
- 利用扩散张力成像 (DTI) 和线性回归来分析结构性大脑连接.
- 根据智商,同时发生的条件和多次测试进行调整,同时控制共享的遗传和环境影响.
主要成果:
- 临床自闭症和自闭症特征都与结构性大脑连接性降低有关.
- 与同胞相比,临床自闭症的双胞胎表现出脑干-状连接性下降.
- 较高的自闭症特征与左海马和左状/副海马区域之间的连接性降低相关.
结论:
- 减少脑干-骨连接可能表明临床自闭症的低水平视觉处理发生变化.
- 自闭症特征中的海马-状网络变化表明对面部和更高阶视觉处理的影响.
- 研究结果表明,遗传和环境因素都会影响这些观察到的大脑连接差异.
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