焦虑的个体将情绪控制从侧面前极转移到背侧面前额皮质
Bob Bramson1,2, Sjoerd Meijer3, Annelies van Nuland3
1Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN, Nijmegen, The Netherlands. bob.bramson@donders.ru.nl.
Nature communications
|August 12, 2023
概括
高度焦虑的人因过度兴奋的侧面前极皮质 (FPl) 而难以控制情绪. 这种神经瓶损害了情绪动作调节,阻碍了学习,增加了回避行为.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 焦虑的特点是情绪行为控制和避免受损.
- 侧面前极皮质 (FPl) 参与通过杏仁体和感觉运动通路协调情绪行为.
研究的目的:
- 在高度焦虑的个体中调查潜在的情绪行动控制缺陷的神经机制.
- 检查侧面前极皮质 (FPl) 在与焦虑相关的行为失调中的作用.
主要方法:
- 利用结构,功能和神经化学成像技术.
- 在参与者中评估了GABA/谷氨酸酸的比率和杏仁管预测.
- 在情绪动作控制任务中分析了功能性大脑招募模式.
主要成果:
- 极度焦虑的个体表现出过度兴奋的FPl,由改变的GABA/谷氨酸酸比率表明.
- 在焦虑的参与者中观察到更强的桃体流体投影.
- 焦虑的个体未能招募FPI,而是利用其他前额叶区域,与FPI兴奋度成比例.
结论:
- 焦虑与FPI介导的情绪动作控制中的电路级脆弱性有关.
- 在轻微的情绪挑战下,FPl神经范围的和会造成瓶,损害行动控制,促进避免.
- 研究结果提供了对焦虑神经基础和潜在治疗点的见解.
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