异常的皮质-甲状腺-小脑网络相互作用及其与精神分裂症患者认知功能受损的关联
Minji Ha1, Soo Hwan Park2, Inkyung Park1
1Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
Schizophrenia (Heidelberg, Germany)
|August 12, 2023
概括
精神分裂症患者表现出大脑连接的改变,特别是涉及丘脑和小脑. 关键大脑网络中的这种异常功能连接 (FC) 与认知缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症中的异常功能连接 (FC) 涉及皮质,丘脑和小脑.
- 泰拉马斯和小脑在内在大脑网络中的综合作用以及它们在精神分裂症中的相互作用仍然不清楚.
研究的目的:
- 为了研究thalamic和小脑网络与精神分裂症皮质网络的综合功能连接.
- 探索精神分裂症患者改变的FC和认知障碍之间的关系.
主要方法:
- 通过合并thalamic,小脑和皮质网络数据生成了一个整合性网络地图.
- 在48名精神分裂症患者和57名健康对照中,在认知网络 (默认模式网络,背部注意网络,突出网络,中央执行网络) 内部和之间比较FC.
- 评估了患者中FC异常和认知功能之间的关联.
主要成果:
- 精神分裂症患者在 Salience 网络 - 中央执行网络, Salience 网络 - 默认模式网络和默认模式网络 - 中央执行网络之间表现出降低的 FC.
- 在患者中观察到中央执行网络内部的连接性较低.
- 默认模式网络和中央执行网络之间的低连接性与认知障碍相关.
结论:
- 丘陵体和小脑在精神分裂症中集成的内在网络中发挥作用.
- 精神分裂症中破坏的三重网络相互作用和认知失衡可能与这些改变的网络动态有关.
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