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Updated: Jun 13, 2026

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生物传感器引导的多基基合成工程优化域交换边界的工程.

Elias Englund1,2, Matthias Schmidt1,3,4, Alberto A Nava1,5

  • 1Joint BioEnergy Institute, Emeryville, CA, USA.

Nature communications
|August 12, 2023
PubMed
概括

研究人员开发了一种生物传感器,以创建新的混合多基酸合成酶 (PKSs). 这种方法可以识别稳定的工程PKS变体,使得能够生产具有改善结构完整性的新分子.

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相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...