在患有肠道衰竭的儿童中,1年肠道自主性的预测因素:描述性的回顾性队列研究
Vikram K Raghu1, Harold J Leraas2, Mariya Samoylova2
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
对于患有肠衰竭 (IF) 的儿童来说,尽量减少肠切除和逆转口腔切除可以加速实现肠道自主. 这项研究确定了影响儿童IF患者早期食成功的关键因素.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床结果研究研究的临床结果.
- 肠道功能衰竭研究 研究肠道功能衰竭
背景情况:
- 肠衰竭 (IF) 显著影响儿科患者的治疗结果.
- 早期实现肠道自主性是管理IF的关键目标.
- 儿童实现肠道自主性的预测因素尚未得到充分理解.
研究的目的:
- 在大型儿科队列中确定早期 (1年) 肠道自主性的预测因素.
- 分析影响FI儿童体内自主性实现时间的因素.
主要方法:
- 利用了国际肠道衰竭登记 (IIFR) 试点阶段的数据.
- 定义的IF是由于胃肠道病因而需要60天以上的肠外营养.
- 采用混合效应的韦布尔加速失效时间模型来分析整个自主性的时间.
主要成果:
- 包括189名儿科患者,51.6%实现了早期的肠道自主.
- 瘤的存在与进入肠道自主性的时间增加有关 (TR, 2.63).
- 较高的肠残留百分比与肠道自主性的时间减少有关 (TR,0.96).
结论:
- 在最初的手术中最大限度地减少肠切除可以减少进入性自主性的时间.
- 通过 ostomy 逆转来建立肠道连续性,可以有效地减少 IF 儿童早期肠道自主性的时间.
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