在SARS-CoV-2感染患者中出现中枢神经系统并发症
Zhonggui Li1, Danyu Lin1, Xiaoshuang Xu1
1Department of Neurology, The Eighth Affiliated Hospital, Sun Yat-Sen University (Futian, Shenzhen), Shenzhen, China.
Journal of neurology
|August 13, 2023
概括
COVID-19可能会导致中枢神经系统 (CNS) 的并发症,如脑炎和脱髓性疾病. 虽然大多数患有这些COVID-19相关的中枢神经系统问题的患者会恢复,但有些人会经历持久的神经功能障碍.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 中枢神经系统 (CNS) 的并发症越来越多地被认为是SARS-CoV-2感染的后果.
- 了解这些神经学表现的临床谱,治疗和结果对于患者管理至关重要.
研究的目的:
- 研究与COVID-19相关的中枢神经系统并发症患者的临床特征,治疗策略和预后.
主要方法:
- 一个单一中心的观察性研究,涉及12名COVID-19相关的中枢神经系统并发症患者.
- 收集的数据包括人口统计,临床症状,脑脊液分析,脑电图,神经成像和治疗结果.
- 患者在出院后被跟踪了1-2个月.
主要成果:
- 中枢神经系统症状在SARS-CoV-2感染后4周内出现,记忆力缺陷,不响应和行为障碍是最常见的.
- 七名患者可能患有SARS-CoV-2脑炎;其他患者出现脑干脑炎,ADEM,视神经炎,多发性硬化或震.
- 9名患者康复良好,2名患者残留功能障碍,1名患者因无关并发症死亡.
结论:
- 炎症和与免疫相关的中枢神经系统并发症,包括各种脑炎表型和脱髓性疾病,在COVID-19中很常见.
- 虽然大多数患者恢复良好,但部分患者可能会出现显著和持续的神经缺陷.
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