高风险患者左心房关闭后较少严重出血和更高的血红蛋白:来自长期,纵向,两中心观察性研究的数据
Christian Schach1, Raphael Reitschuster1, Dennis Benedikt1
1Department for Internal Medicine II, University Heart Center Regensburg, Regensburg, Germany.
Clinical cardiology
|August 13, 2023
概括
左心房尾关闭 (LAAC) 减少了心房动 (AF) 患者的中风和出血,患者不能容忍口服抗凝剂 (OAC). 这种程序导致出血事件显著减少,血清血红蛋白水平增加.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 预防中风 预防中风
背景情况:
- 左心房尾关闭 (LAAC) 为预防中风提供了一种机械替代方案.
- 它适用于那些不能容忍口服抗凝剂 (OAC) 的风险患者.
研究的目的:
- 调查LAAC后减少抗凝血是否会减少出血事件并增加血清血红蛋白.
- 为了评估高风险心房动 (AF) 患者的这些结果.
主要方法:
- 对出血事件,输血,抗凝血,栓塞事件和血清血红蛋白水平的回顾性分析.
- 在超过4年的随访期内,LAAC前后数据的比较.
主要成果:
- 分析了75名高风险的AF患者 (CHA2DS2-VASc得分为4.4,HAS-BLED得分为4.6).
- 在LAAC后,出血事件 (每年0.6比1.8) 和重大出血 (每年0.2比0.9) 显著减少.
- 脑卒中发生率下降 (3对14名患者),血清血红蛋白从9.9升至11.9g/dL (p=0.0005).
结论:
- 在高风险的AF患者中,LAAC有效地降低了对OAC不耐受的中风和出血率.
- 降低出血事件与血清血红蛋白度显著增加相关.
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